Polycythemia Vera Signs and Symptoms

Polycythemia Vera Is Associated With Significant Symptom Burden

The signs and symptoms of PV may be similar to those of other myeloproliferative neoplasms.

Although patients with PV may be asymptomatic for many years, the disease is associated with substantial symptom burden.

Fatigue is the most common and most intense symptom reported.1

Symptoms can be associated with splenomegaly.2 Symptomatic or progressive splenomegaly may warrant further evaluation.

ACCESS A TOOL TO HELP YOUR PATIENTS WITH PV TRACK THEIR SYMPTOMS OVER TIME

Self-Reported Symptoms of Polycythemia Vera1
image of graph that shows the percentage of self-reported polycythemia vera symptoms broken out by symptoms
Symptom assessment of 538 patients with polycythemia vera. Incidence is a score of >0 on the Myeloproliferative Neoplasm-Symptom Assessment Form Total Symptom Score (MPN-SAF TSS). Symptom severity was rated on a 0 (absent/as good as it can be) to 10 (worst imaginable/as bad as it can be) scale.1 The MPN-SAF TSS has a possible range of 0 to 100, with 100 representing the highest level of symptom severity. Fatigue was independently measured by coadministration of the Brief Fatigue Inventory.1
References

1. Emanuel RM, Dueck AC, Geyer HL, et al. J Clin Oncol. 2012;30:4098-4103. 2. Barbui T, Barosi G, Birgegard G, et al. J Clin Oncol. 2011;29:761-770.

 
Resources
The potential impact of a target hematocrit level of <45% on major thrombosis or cardiac death.
By: MPN Connect
An animated video highlighting PV pathophysiology and mechanisms of disease.