ET is a chronic disease that may transform to MF

Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) characterized by thrombocytosis with bone marrow megakaryocytic hyperplasia and a tendency to develop thrombotic and hemorrhagic complications.1-3

In some patients, ET may transform to myelofibrosis (MF), called post-ET MF.4 ET can also transform to secondary acute myelogenous leukemia in a small minority of patients.5

References: 1. Cervantes F. Hematology Am Soc Hematol Educ Program. 2011;2011:215-221. 2. Tefferi A, Barbui T. Leukemia. 2013;27(8):1617-1620. 3. Wolanskyj AP, Schwager SM, McClure RF, Larson DR, Tefferi A. Mayo Clin Proc. 2006;81(2):159-166. 4. Verstovsek S. Clin Cancer Res. 2010;16(7):1988-1996. 5. Abdel-Wahab O, Manshouri T, Patel J, et al. Cancer Res. 2010;70(2):447-452.

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