PV symptoms may impact patients and can exist despite treatment1-3
![Image that says – In the Landmark survey, 66% of patients with PV reported that their symptoms reduced their quality of life](/sites/g/files/hssmmz4366/files/2022-01/Group%209.png)
![Image that says – In the Landmark survey, 66% of patients with PV reported that their symptoms reduced their quality of life](/sites/g/files/hssmmz4366/files/2022-01/Asset%202%402x_1.png)
The MPN Landmark survey, funded by Incyte Corporation, was a web-based questionnaire composed of 65 multiple-choice questions intended to help evaluate the patient disease burden in the myeloproliferative neoplasm (MPN) disease setting. A total of 813 patients in the US with a previous diagnosis of myelofibrosis (MF), PV, or essential thrombocythemia (ET) completed the survey (MF, n = 207; PV, n = 380; ET, n = 226).1
Patients reported whether they strongly agreed, somewhat agreed, somewhat disagreed, or strongly disagreed with the following statement: PV symptoms reduce my quality of life.1,4
PV-related symptoms carry a real impact. Learn about how these patients carried the burden
![Image leads to video of a real PV patient named Dave, who speaks about how PV symptom burden impacts his life](/sites/g/files/hssmmz4366/files/2022-01/thumbnail_1_1.png)
30 nights spent sweating since Dave’s last PV appointment. (But who’s counting?)
Dave, a patient with PV, is experiencing
disease-related symptoms. He sees his oncologist every 3 months. Learn how night sweats, and other symptoms of PV, impacted Dave's life.
![Image leads to video of a real PV patient named Nick, who speaks about how PV symptom burden made him miss out on important moments](/sites/g/files/hssmmz4366/files/2022-01/thumbnail_2_2.png)
40 days lost to fatigue since Nick’s last PV appointment. (But who’s counting?)
Nick, a patient with PV, is experiencing
disease-related symptoms. He sees his oncologist every 3 months. Learn how fatigue, and other symptoms of PV, made him miss out on important moments.
![Image leads to video of a real PV patient named Julie, who speaks about how PV symptom burden affected her life](/sites/g/files/hssmmz4366/files/2022-02/Rectangle%20Copy%207.png)
36 days of itching since Julie's last PV appointment. (But who's counting?)
Julie, a patient with PV, is experiencing disease-related symptoms. She sees her oncologist every 3 months. Learn how pruritus, and other symptoms of PV, affected her life.
![](/sites/g/files/hssmmz4366/files/2022-01/circle_portrait_1.2_1.png)
I cannot emphasize enough that PV-related symptoms are prevalent and may impact your patient’s quality of life. Based on my own experience, if you ask specific, detailed questions about PV-related symptoms—such as fatigue, night sweats, or pruritus, among others—you may find that your patients are experiencing one or more [of] these symptoms to some degree.
—Prithviraj Bose, MD
White Paper—Optimizing the Management of Patients with Polycythemia Vera
On average, patients with known HU use had moderately high symptom burden (TSS = 29.2)2
- A prospective study of 1334 patients with PV where a subset of patients received hydroxyurea (HU) (n = 499)2‡
![Image of graph that shows MPN-10 mean symptom scores in patients with known HU use](/sites/g/files/hssmmz4366/files/2021-11/Asset%20388%404x.png)