Essential Thrombocythemia Signs and Symptoms

ET Is Associated With a Variety of Nonspecific Signs and Symptoms

Symptoms and signs of ET include1:

  • Erythromelalgia (burning or throbbing pain in the feet)
  • Symptoms associated with compromised cerebral blood flow:
    • Headache
    • Dizziness
    • Weakness or numbness on one side of the body
    • Slurred speech
  • Fatigue/weakness
  • Itching
  • Sweating
  • Low-grade fever
  • Thrombosis
  • Unexpected or exaggerated bleeding
  • Enlarged spleen
Self-Reported Symptoms of Essential Thrombocythemia2
image of graph that shows the percentage of self-reported essential thrombocythemia symptoms broken out by symptoms
Symptom assessment of 594 patients with essential thrombocythemia. Incidence is a score of >0 on the Myeloproliferative Neoplasm-Symptom Assessment Form Total Symptom Score (MPN-SAF TSS). Symptom severity was rated on a 0 (absent/as good as it can be) to 10 (worst imaginable/as bad as it can be) scale.2 The MPN-SAF TSS has a possible range of 0 to 100, with 100 representing the highest level of symptom severity. Fatigue was independently measured by coadministration of the Brief Fatigue Inventory.2

1. The Leukemia & Lymphoma Society. White Plains, NY; 2012. Number 12. 2. Emanuel RM, Dueck AC, Geyer HL, et al. J Clin Oncol. 2012;30:4098-4103.