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Recognzing Polycythemia Vera (PV) That Has Become Advanced

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My name is Lindsey Lyle. I'm a Physician Assistant and Senior Instructor at the University of Colorado Cancer Center in Denver.

Clinical characteristics of advanced polycythemia vera are patients who are currently on treatment with hydroxyurea and phlebotomy, however, continue to have hematocrit greater than 45% plus an elevated white blood cell count greater than 11,000 or symptoms of the disease. And this occurs in a subset of patients.

It is important to monitor patients with advanced polycythemia vera because this can be a dynamic process and the disease can change over time. Hematocrit levels may increase over time, white blood cells may increase over time, and symptoms may worsen.

In my practice, in patients with advanced polycythemia vera, I may see them more frequently. Perhaps once a week in the event of an acute change in their disease process or once a month in order to achieve the goals that I want to achieve.

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Lindsey Lyle, MS, PA-C Physician Assistant and Senior Instructor University of Colorado Cancer Center | Aurora, CO
Ms Lyle's clinical focus includes benign hematologic disorders and hematologic malignancies, with a special interest in myeloproliferative neoplasms (MPNs). Her clinical philosophy focuses on treating the person as a whole, taking every aspect of a patient’s physical and mental health into consideration during diagnosis and treatment. A national and regional speaker on hematologic malignancies, she is also involved in rural health outreach and improving health literacy among young people.